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An important contributor to leptin resistance is changes to leptin receptor signalling, particularly in the arcuate nucleus , however, deficiency of, or major changes to, the leptin receptor itself are not thought to be a major cause. Insights from mouse models of obesity". In , a non-obese mouse colony being studied at the Jackson Laboratory produced a strain of obese offspring, suggesting that a mutation had occurred in a hormone regulating hunger and energy expenditure. Crit Rev Food Sci Nutr. The insulin increase in response to the caloric load provokes a dose-dependent rise in leptin, an effect potentiated by high cortisol levels. Treatment with metreleptin led to "rapid change in eating behavior, a reduction in daily energy intake, and substantial weight loss". A single case of a homozygous transversion mutation of the gene encoding for leptin was reported in January


This generally causes people to give up on their diet and gain the weight back. For this reason, most conventional weight loss methods have a terrible success rate. Very few people succeed in the long run. This is where a popular weight loss supplement called Garcinia Cambogia extract steps in. According to many health experts, it can reduce appetite and help you lose weight, pretty much without effort.